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... studies in ITP, MDS, CIT Romiplostim exposure in BLA: n = 271 in ITP n = 121 in other settings Phase 3: Studies 20030105 and 20030212 Study “105:” Splenectomy ...

Restarted on prednisone 60 mg QD. 10/6/04 lap splenectomy 2 days later plt = 85K and prednisone was tapered over 1 month to 20 mg QOD. 11/3/04 plt again < 10K with ...

REFRACTORY ITP Persistence of thrombocytopenia after initial therapy, including splenectomy, with the need of active treatment to maintain a safe platelet count or to ...

In 1993 he developed Hemophilus influenzae sepsis and meningitis SPLENECTOMY Risk of overwhelming infections is increased (~2.5 to 3.5% of patients will have a serious ...

Most adults will get chronic disease Absolutely no consensus on what to do Splenectomy Rates of splenectomy falling in USA Many patients options for medical therapy ...

AGENDA Select Topics EVALUATION SPLEEN HISTORY 1900s 100% Mortality with NOM Splenectomy treatment of choice 1952 Five cases of fatal infections in infants following ...

... β-Thalassemia Major Treatment Regular transfusions Minimize anemia Suppress ineffective erythropoiesis Iron-chelating agents Reduce excess iron absorption Splenectomy ...

... 3 of the platlet mass – in massive splenomegaly this can lead to peripheral thrombocytopenia (decrease in platlets in the peripheral blood) After a splenectomy (removal ...

Treatment – surgery a. children – delayed surgical management b. adult - splenectomy c. splenectomized patients should receive pneumovax Haemophilus ...

Splenectomy sometimes is recommended as therapy for severe cases & can result in amelioration of the disease. Patients who have undergone splenectomy are @ increased ...

History Immunological importance of the spleen Morris and Bullock-1919 First post-splenectomy infection O’Donnell-1929 Effects of Hyposplenism King and Shumacker-1952 ...

... and splenectomy 143 minutes 1 severe pancreatitis made mobilization difficult Thompson retractor Results 2 patients failed due to bleeding, resulting in splenectomy 13 ...

Tx with IV antibiotics but died of acute renal failure and acute respiratory distress syndrome 3 days after ER presentation No Hx of splenectomy or immunosuppression ...

Patient. Female in early 20’s presents with abdominal discomfort and feelings of early satiety. On physical exam, a palpable mass is found in the left upper ...

Post-Splenectomy Sepsis 1930’s – Early post-surgical studies showed no increase in sepsis after splenectomy 1952 – King & Schumacker describe 5 infants post ...

Splenectomy no appropriate in mild or mod thrombocytopenia and minor bleeding Indication for Splenectomy in ITP Splenectomy should be deferred for 4-6 weeks after ...

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