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... and Lys residues Human ubiquitin sequence MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG Ubiquitination Post-translational modification ...

Molecular Diversity and its Control Post-translational Modification: ~ 5-10% of a subunit MW can be glycosylation. Oligomannosidic glycans + complex oligosaccharides.

Example of a PROSITE record PROSITE Database Cont. 1 Families of proteins have a similar function: Enzyme activity Post-translational modification Domains-Ca2 ...

What proteomics can answer Protein identification Protein Expression Studies Protein Function Protein Post-Translational Modification Protein Localization and ...

... own biosynthetic processes to introduce detectable markers in newly-synthesized molecules DNA Replication Transcription Translation Post-translational Modification ...

This can occur by transcriptional regulation or post-translational modification. Transcriptional Regulation Specific transcription factors bind directly to specific ...

... Genetic abnormalities of collagen mutations that lead to aminoacid deletions or additions deficient synthesis of a portion disorders in post-translational modification ...

A very important post-translational modification is the folding of the protein into it’s appropriate 3-dimensional shape as is shown by the folding of the protein in ...

DNA RNA Protein Transcription Translation Post-translational modification >300 types: Phosphorylation, glycosylation, lipidation, acetylation, proteolysis…

Example: By regulating how luteinizing hormone is glycosylated (post-translational modification step), you can create LH molecules with different biological activities.

Mann and O. N. Jensen, “Proteomic analysis of post-translational modification.” Nature Biotech. 2003; 21: 255-261. D. T. McLachlin and B. T. Chait, “Analysis of ...

Feautures of ISPTM Targets for Future References Acknowledgements Post-translational modification is the chemical modification of a protein after its translation.

COURSE G351 01-20-09 MOLECULAR AND CELLULAR NEUROBIOLOGY Translation II: Protein targeting and post-translational modification Alberts 4th ed pp 664-675, 678-686, 689 ...

16-1 Protein modification Protein modifications different types, including co-translational and post-translational inteins It is estimated that the human proteome ...

Purposes of post-translational modifications 2. Quality control in the cytoplasm Quality control in the ER 4. Selective post-translational proteolysis

Post-Translational Modification New polypeptides usually fold themselves spontaneously into their active conformation. However, some proteins are helped and guided in ...

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